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高分子・バイオ材料研究センター バイオ材料分野 医療応用ソフトマターグループ
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論文
2026
- Ryoma Takagi, Tadashi Nakaji-Hirabayashi, Moe Kato, Miwako Shobo, Chiaki Yoshikawa. Durable and biofunctional polydimethylsiloxane surfaces engineered with photocrosslinkable terpolymers for aligned and functional myotube formation. Biomaterials and Biosystems. 21 100126-100126-10. 2026. Open Access
- Kohsaku Kawakami, Ryo Mizoguchi, Taichi Ishitsuka, Akira Suzuki, Jun Nakagomi, Katsutoshi Yamaguchi, Hitomi Okada, Yuya Ishizuka, Takahiko Hashizuka. Determination of nucleation temperature of pharmaceutical glasses by thermal analysis. Thermochimica Acta. 759 180262-180262-14. 2026. Open Access
- Anamika Verma, Nitisha Beniwal, Chandra Lekha Putta, Sasvat Sayee Ram Ramesh, Sajmina Khatun, Soumitra Pathak, Tomohiko Yamazaki, Aravind Kumar Rengan. CpG ODNs: Precision Immunotherapy and Recent Trends in Nano-Enabled Nucleotide Delivery. Critical Reviews™ in Therapeutic Drug Carrier Systems. 43 [1] 57-95. 2026. Open Access
- Chiho Kataoka-Hamai, Waka Nakanishi, Shinya Hattori. Incorporationof Oligo(Styrene), Oligo(Butadiene),Oligo(Methyl Methacrylate), and Oligo( tert -ButylAcrylate) Droplets in Giant Unilamellar Vesicles. Langmuir. 42 [34] 24915-24925. 2026. Open Access
- Paulina Poloczek, Justyna Knapik-Kowalczuk, Joanna Klimontko, Xue Han, Kohsaku Kawakami, Marian Paluch. Eutectic-Driven Recrystallization of Coamorphous Bicalutamide + Niclosamide Systems: Contrasting Stability above and below T g. Molecular Pharmaceutics. 23 [7] 3641-3653. 2026. Open Access
- Wenyan Lyu, Katsuhiko Ariga, Jingwen Song. Programmable Nanoarchitectonics for Artificial Cells via Coupled Multidimensional Regulation of Phase State and Multiscale Transport Dynamics. ACS Applied Materials & Interfaces. 18 [23] 32406-32418. 2026. Open Access
- Takeru Kanazu, Erika Komiya, Daimei Miura, Kaori Tsukakoshi, Kazunori Ikebukuro, Tomohiko Yamazaki, Ryutaro Asano. Turning on Protein Function Inhibited by DNA Aptamers Employing a Covalent DNA-Binding Protein. ACS Nanoscience Au. 6 [2] 201-207. 2026. Open Access
- Lingying Li, Shunto Arai, Mayumi Kumada, Takeshi Yasuda, Kenji Sakamoto, Kohsaku Kawakami, Masafumi Yoshio, Takeo Minari. Synergistically Coordinated Ni Complex Ink for Low‐Temperature and Highly Reliable Printed Electronics. Advanced Functional Materials. 36 [22] e25338-1-e25338-11. 2026. Open Access
- Katsuhiko Ariga, Jingwen Song, Kohsaku Kawakami. Protein nanoarchitectonics at liquid-related interfaces: physicochemical communications with biological processes. Chemical Communications. 62 [16] 4670-4692. 2026. Open Access
- Sachiko Hiromoto, Kazuma Midorikawa, Tomohiko Yamazaki, Tomoyuki Yamamoto. Control of Corrosion Resistance and Osteoclastic Resorbability of Bioresorbable Carbonate Apatite Coating for Biodegradable Mg Alloys through Carbonate Content. ACS Biomaterials Science & Engineering. 12 [1] 322-334. 2026. Open Access
- Xue Han, Kaoru Ohyama, Kohsaku Kawakami. Influence of the Addition of Trace Amounts of Vinylpyrrolidone–Vinyl Acetate Copolymer (PVPVA) on the Crystallization of Celecoxib Glass. Molecular Pharmaceutics. 23 [1] 280-292. 2026. Open Access
2025
- Jingwen Song, Kohsaku Kawakami, Katsuhiko Ariga. Localized assembly in biological activity: Origin of life and future of nanoarchitectonics. Advances in Colloid and Interface Science. 339 103420-103420-36. 2025. Open Access
- Soumitra Pathak, Nguyen Bui Thao Le, Taiji Oyama, Yusuke Odahara, Atsuya Momotake, Kazunori Ikebukuro, Chiho Kataoka-Hamai, Chiaki Yoshikawa, Kohsaku Kawakami, Yoshihisa Kaizuka, Tomohiko Yamazaki. Immunostimulatory Effects of Guanine-Quadruplex Topologies as Scaffolds for CpG Oligodeoxynucleotides. Biomolecules. 15 [1] 95-95-16. 2025. Open Access
- Xizi Long, Chiho Kataoka-Hamai, Chia-Lun Ho, Wei-Lun Huang, Yi-Ho Kuo, Li-Ting Yang, Wei-Peng Li, Akihiro Okamoto. Scalable liposomes functionalization via membrane lipid exchange mechanisms. Nano Today. 61 102630-102630-10. 2025. Open Access
- Kohsaku Kawakami. Roles of Supersaturation and Liquid–Liquid Phase Separation for Enhanced Oral Absorption of Poorly Soluble Drugs from Amorphous Solid Dispersions. Pharmaceutics. 17 [2] 262-262-17. 2025. Open Access
- Gabriel Tai Huynh, Jun Qiu, Edith van den Bosch, Tomohiko Yamazaki, Chiaki Yoshikawa. Concentrated Polymer Brush-Modified Magnetic Particles for a Diagnostic Immunoassay. Langmuir. 41 [48] 32432-32442. 2025. Open Access
- Shiho Tsutsumi, Yuki Takechi-Haraya, Yasuhiro Abe, Kohsaku Kawakami. Impact of Lipid Bilayer Composition and Physicochemical Properties on Constitution of a Transmembrane Helical Peptide into Exosome-Mimetic Vesicles. Molecular Pharmaceutics. 22 [11] 6874-6886. 2025. Open Access
- Yoshihisa Kaizuka, Rika Machida. Cell membrane glycan contents are biochemical factors that constitute a kinetic barrier to viral particle uptake in a protein-nonspecific manner. eLife. 14 RP101175-1-RP101175-31. 2025. Open Access
- Katsutoshi Yamaguchi, Yuya Ishizuka, Etsushi Yoshikawa, Takashi Makishima, Ryo Mizoguchi, Kohsaku Kawakami. Nucleation in Amorphous Terfenadine at a Temperature Much Lower than the Glass Transition Temperature and Its Impact on Physical Stability. Molecular Pharmaceutics. 22 [10] 6038-6049. 2025. Open Access
- Katsuhiko Ariga, Jingwen Song, Kohsaku Kawakami. From Inception to Innovation: 20 Years of Nanoarchitectonics. Chemistry – An Asian Journal. 20 [20] e00836-1-e00836-41. 2025. Open Access
- Chiho Kataoka-Hamai. Quantifying the Thresholds of the Phospholipid Surface Density for Nonspecific Protein Adsorption and Desorption at the Triacylglycerol/Water Interface. Langmuir. 41 [37] 25431-25438. 2025. Open Access
- Dani Lakshman Yarlagadda, Kohsaku Kawakami, Satyavrata Samavedi. Leveraging Molecular Interactions to Develop a Generalized Design Framework for Coamorphous Drug–Drug Mixtures Exhibiting Elevated Glass Transition Temperatures. Molecular Pharmaceutics. 22 [6] 3084-3096. 2025. Open Access
- Xue Han, Kohsaku Kawakami. Influence of Pore Size of Mesoporous Silica on Physical Stability of Overloaded Celecoxib Glass. Molecular Pharmaceutics. 22 [5] 2556-2567. 2025. Open Access
- Qicheng Zhang, Si Chen, Xiaoting Xue, Solmaz Hajizadeh, Tomohiko Yamazaki, Lei Ye. Cationic Polymer Brushes Functionalized with Carbon Dots and Boronic Acids for Bacterial Detection and Inactivation. ACS Omega. 10 [14] 14536-14546. 2025. Open Access
- Yoshihide Tokunou, Tomohiko Yamazaki, Takashi Fujikawa, Akihiro Okamoto. Decoding in-cell respiratory enzyme dynamics by label-free in situ electrochemistry. Proceedings of the National Academy of Sciences. 122 [12] e2418926122-1-e2418926122-12. 2025. Open Access
- Chiho Kataoka-Hamai, Jingwen Song, Kohsaku Kawakami. Incorporation of Triacylglycerol and Cholesteryl Ester Droplets in Phase-Separated Giant Unilamellar Vesicles. Langmuir. 41 [9] 6113-6123. 2025. Open Access
- Kohsaku Kawakami, Kaoru Ohyama. Crystal Nucleation in Ibuprofen Glass: Possible Relevance between the Characteristic Length of the Cooperatively Rearranging Region and the Size of Crystal Nuclei. The Journal of Physical Chemistry B. 129 [7] 2096-2104. 2025. Open Access
- Kohsaku Kawakami, Taichi Ishitsuka, Masafumi Fukiage, Yohei Nishida, Tetsuo Shirai, Yosuke Hirai, Tetsu Hideshima, Fumiaki Tanabe, Koji Shinoda, Ryota Tamate, Takuya Fujita. Long-term physical stability of amorphous solid dispersions: Comparison of detection powers of common evaluation methods for spray-dried and hot-melt extruded formulations. Journal of Pharmaceutical Sciences. 114 [1] 145-156. 2025. Open Access
- Michinori Oikawa, Satoru Matsuura, Takeyuki Okudaira, Ryo Ito, Kanako Arima, Masahiro Fushimi, Takamasa Oda, Kaoru Ohyama, Kohsaku Kawakami. Bridging the gap between in vitro and in vivo solubility-permeability interplay. Journal of Pharmaceutical Sciences. 114 [1] 361-370. 2025. Open Access
2024
- Angela Quispe-Salcedo, Tomohiko Yamazaki. Effects of Synthetic Toll-Like Receptor 9 Ligand Molecules on Pulpal Immunomodulatory Response and Repair after Injuries. Biomolecules. 14 [8] 931-931-16. 2024. Open Access
- Febriana Catur Iswanti, Tomohiko Yamazaki. Lysosomal enzymes and the oxygen burst capability of monocyte-derived macrophages in active drug-resistant tuberculosis patients in relation to cell attachment. Tuberculosis. 146 102498-102498-10. 2024. Open Access
- Kazuaki Hoshi, Anh Thi Tram Tu, Miwako Shobo, Karin Kettisen, Tomohiko Yamazaki. Potential of Enzymatically Synthesized Hemozoin Analog as Th1 Cell Adjuvant. Nanomaterials. 14 [17] 1440-1440-13. 2024. Open Access
- Dijana Jelić, Miho Araki, Kohsaku Kawakami. Isoconversional kinetic analysis of thermal decomposition of Bidirectionally stabilized amorphous formulation loading Vitamin D3 (Cholecalciferol) and Calcium Carbonate. Thermochimica Acta. 736 179740-179740-11. 2024. Open Access
- Xia Li, Mitsuhiro Ebara, Naoto Shirahata, Tomohiko Yamazaki, Nobutaka Hanagata. Synergistic Effects of Metal–Organic Nanoplatform and Guanine Quadruplex-Based CpG Oligodeoxynucleotides in Therapeutic Cancer Vaccines with Different Tumor Antigens. Vaccines. 12 [6] 649-649-14. 2024. Open Access
- Xia Li, Shinya Hattori, Tomohiko Yamazaki, Mitsuhiro Ebara, Naoto Shirahata, Nobutaka Hanagata. Inosine pranobex-derived coordination complexes for self-adjuvant, self-carrier, and self-assembled vaccines in cancer immunotherapy. Applied Materials Today. 39 102299-102299-16. 2024. Open Access
- Jingwen Song, Anna Jancik-Prochazkova, Kohsaku Kawakami, Katsuhiko Ariga. Lateral nanoarchitectonics from nano to life: ongoing challenges in interfacial chemical science. Chemical Science. 15 [45] 18715-18750. 2024. Open Access
- Jingwen Song, Wenyan Lyu, Kohsaku Kawakami, Katsuhiko Ariga. Bio-gel nanoarchitectonics in tissue engineering. Nanoscale. 16 [28] 13230-13246. 2024. Open Access
- Chiho Kataoka-Hamai. Triacylglycerol-droplet-induced bilayer spontaneous curvature in giant unilamellar vesicles. Biophysical Journal. 123 [13] 1857-1868. 2024. Open Access
- Shoko Takeuchi, Tomohiko Yamazaki, Kohsaku Kawakami. Toward the Establishment of a Harmonized Physicochemical Profiling Platform for Therapeutic Oligonucleotides: A Case Study for Aptamers Where the Higher-Order Structure Influences Physical Properties. Molecular Pharmaceutics. 21 [7] 3471-3484. 2024. Open Access
- Xia Li, Naoto Shirahata, Tomohiko Yamazaki, Nobutaka Hanagata. A rapid strategy to develop personalized cancer nanovaccines for different immunogenic tumors.. Journal of Clinical Oncology. 42 [16_suppl] e14670-e14670. 2024. Open Access
- Katsuhiko Ariga, Jingwen Song, Kohsaku Kawakami. Molecular machines working at interfaces: physics, chemistry, evolution and nanoarchitectonics. Physical Chemistry Chemical Physics. 26 [18] 13532-13560. 2024. Open Access
- Xue Han, Kexin Dai, Kohsaku Kawakami. Influence of Nucleation on Relaxation, Molecular Cooperativity, and Physical Stability of Celecoxib Glass. Molecular Pharmaceutics. 21 [4] 1794-1803. 2024. Open Access
- Katsuhiko Ariga, Jingwen Song, Kohsaku Kawakami. Layer-by-layer designer nanoarchitectonics for physical and chemical communications in functional materials. Chemical Communications. 60 [16] 2152-2167. 2024. Open Access
2023
- Nguyen Bui Thao Le, Anh Thi Tram Tu, Dandan Zhao, Chiaki Yoshikawa, Kohsaku Kawakami, Yoshihisa Kaizuka, Tomohiko Yamazaki. Influence of the Charge Ratio of Guanine-Quadruplex Structure-Based CpG Oligodeoxynucleotides and Cationic DOTAP Liposomes on Cytokine Induction Profiles. Biomolecules. 13 [11] 1639. 2023. Open Access
- Febriana Catur Iswanti, Tomohiko Yamazaki. The Use of Chitosan Nanoparticles for Delivery of CpG ODN in Treatment of Allergic Balb/C Mice. Reports of Biochemistry and Molecular Biology. 11 [4] 599-613. 2023.
- Anchu Viswan, Chiaki Yoshikawa, Tomohiko Yamazaki. Efficient genome editing by controlled release of Cas9 ribonucleoprotein in plant cytosol using polymer-modified microneedle array. Biochemical and Biophysical Research Communications. 686 149179. 2023.
- Tamaki Miyazaki, Kohsaku Kawakami. Crystallization of Amorphous Nifedipine Under Isothermal Conditions: Inter-laboratory Reproducibility and Investigation of the Factors Affecting Reproducibility. Journal of Pharmaceutical Sciences. 112 [10] 2703-2716. 2023.
- Wenyan Lyu, Jingwen Song, Jun Nakanishi, Xiaofang Jia. Manipulating the Dynamic Adaptivity of a Fluid Interface to Maintain the Multipotency of Mesenchymal Stromal Cells. Advanced Healthcare Materials. 12 [24] 2300666. 2023.
- Jingwen Song, Kohsaku Kawakami. Nucleation During Storage Impeded Supersaturation in the Dissolution Process of Amorphous Celecoxib. Molecular Pharmaceutics. 20 [8] 4050-4057. 2023.
- Chiho Kataoka-Hamai, Kohsaku Kawakami. Ostwald Ripening of Triacylglycerol Droplets Embedded in Glass-Supported Phospholipid Bilayers. Langmuir. 39 [29] 10001-10010. 2023.
- Kohsaku Kawakami. Rigid Nuclei and Flexible Nuclei: Appearance and Disappearance of Nuclei in Indomethacin Glass Revealed by a Long-Term Annealing Study. The Journal of Physical Chemistry B. 127 [26] 5967-5977. 2023.
- Kohsaku Kawakami, Junko Tanaka, Chiho Kataoka-Hamai. Solubilization of organic liquid into water using mesoporous phospholipid particles. Sustainable Materials and Technologies. 36 e00642. 2023.
- Xia Li, Tomohiko Yamazaki, Mitsuhiro Ebara, Naoto Shirahata, Nobutaka Hanagata. Nanoengineered coordination polymers boost cancer immunotherapy. Materials Today. 67 127-150. 2023.
- Usharani Nagarajan, Sourov Chandra, Tomohiko Yamazaki, Naoto Shirahata, Françoise M. Winnik. Analysis of Silicon Quantum Dots and Serum Proteins Interactions Using Asymmetrical Flow Field-Flow Fractionation. Langmuir. 39 [22] 7557-7565. 2023.
- Jingwen Song, Kohsaku Kawakami, Katsuhiko Ariga. Nanoarchitectonics in combat against bacterial infection using molecular, interfacial, and material tools. Current Opinion in Colloid & Interface Science. 65 101702. 2023.
- Yoshihisa Kaizuka, Rika Machida. Antiviral Activity of Cell Membrane-Bound Amphiphilic Polymers. Langmuir. 39 [15] 5408-5417. 2023.
- Xuechen Shen, Jingwen Song, Kohsaku Kawakami, Katsuhiko Ariga. Zero to zero nanoarchitectonics with fullerene: from molecules to nanoparticles. Journal of Nanoparticle Research. 25 [3] 45. 2023.
- Tomohiro Murata, Kosuke Minami, Tomohiko Yamazaki, Tomomasa Sato, Katsuhiko Ariga. Nanometer-Flat DNA-Featured Thin Films Prepared via Laser Molecular Beam Deposition under High-Vacuum for Selective Methanol Sensing. Bulletin of the Chemical Society of Japan. 96 [1] 29-34. 2023. Open Access
書籍
2026
- KAWAKAMI, Kohsaku. Physical Stability of Amorphous Drugs and Amorphous Solid Dispersions. Amorphous Solid Dispersions. 2026.
2025
- KAWAKAMI, Kohsaku. Nuclei Formation in Pharmaceutical Glasses. Advances in Organic Crystal Chemistry: Comprehensive Reviews 2025 on Crystal Structures. 2025.
2024
- LI, Xia, YAMAZAKI, Tomohiko, EBARA, Mitsuhiro, SHIRAHATA, Naoto, HANAGATA, Nobutaka. Rational Design of adjuvants boosts cancer vaccines. Progress in Molecular Biology and Translational Science: Cancer Immunotherapy . 2024. Open Access
- 山崎 智彦. バイオキャパシタ原理を用いた自立型グルコースセンサ. 血糖測定・コントロールの 最新動向. 2024.
2023
- 岡田弘晃, 川上 亘作. 製剤設計・製造技術 Basic Frontier. 製剤設計・製造技術 Basic & Frontier. 2023.
- KAWAKAMI, Kohsaku. Particle Architectonics for Pulmonary Drug Delivery. Organ Specific Drug Delivery and Targeting to the Lungs. 2023.
- 川上 亘作. 難水溶性薬物のための経口製剤化技術. 製剤設計・製造技術 Basic & Frontier. 2023.
- 川上 亘作, 岡田弘晃. 製剤設計・製造技術 Basic Frontier. 製剤設計・製造技術 Basic & Frontier. 2023.
口頭発表
2026
- KAWAKAMI, Kohsaku. Harmonization of a Physicochemical Profiling Platform ofTherapeutic Oligonucleotides. AAPS 2026 Summer Scientific Forum. 2026. 招待講演
- KAWAKAMI, Kohsaku. Glass science to elevate poorly soluble drugs to promising candidates. Pharm CU-Japan Symposium on the Translation of Advanced Biomaterials into Practical Advanced Therapy Products. 2026. 招待講演
- 片岡 知歩. トリアシルグリセロール/水界面でのタンパク質の吸着と脱離:リン脂質表面密度による制御. 2026年 第73回 応⽤物理学会春季学術講演会. 2026.
- KAWAKAMI, Kohsaku. Relevance between molecular cooperativity and nucleation of organic glasses. XVII International Workshop on Complex Systems. 2026.
2025
- YAMAZAKI, Tomohiko, レ ボイ タオ グエン. Effect of the particle size on the immunostimulatory properties of guanine quadruplex-formed CpG oligodeoxynucleotides. 18th International Symposium on Nanomedicine (ISNM 2025) . 2025.
- YAMAZAKI, Tomohiko, Taiji OYAMA, Kazuori Ikebukuro, KAWAKAMI, Kohsaku. Spectroscopic characterization of the structure of therapeutic oligonucleotides at high concentrations. TIDES Europe 2025. 2025.
- HIROMOTO, Sachiko, 緑川 壱丸, YAMAZAKI, Tomohiko, 山本 知之. Control of Corrosion Resistance and Osteoclastic Resorption of Carbonate Apatite Coating on Magnesium via Carbonate Content. 第47回日本バイオマテリアル学会大会. 2025.
- KAWAKAMI, Kohsaku. Physical Chemistry for Practical Pharmaceutical Science. Biopham Master Program. 2025. 招待講演
- KAWAKAMI, Kohsaku. Physical Stabilization of Organic Glasses by Controlling Local Molecular Mobility. The 11th Southeast Asia Collaborative Symposium on Energy Materials. 2025. 招待講演
- 谷田部 舞桜, 山崎 智彦, 小林玉枝, Anders Bjartell. グアニン四重鎖構造を形成するオリゴ核酸によるがん細胞増殖抑制効果. 2025年 繊維学会秋季研究発表会. 2025.
- 山崎 智彦, 谷田部 舞桜, 池袋一典. グアニン四重鎖による未修飾核酸アジュバントの機能強化. 第20回ナノ・バイオメディカル学会大会. 2025.
- YAMAZAKI, Tomohiko. Apatite nanoparticle boost immunostimulatory effect and antibody production of non-modified DNA-based adjuvants. The Fifteenth International Conference on the Science and Technology for Advanced Ceramics 2025 (STAC-15). 2025. 招待講演
- YAMAZAKI, Tomohiko. Apatite nanoparticle boost immunostimulatory effect and antibody production of non-modified DNA-based adjuvants. The Fifteenth International Conference on the Science and Technology for Advanced Ceramics (STAC-15). 2025. 招待講演
- KAWAKAMI, Kohsaku. Stabilization of Overloaded Pharmaceutical Glass Using Mesoporous Silica Particles. Materials Oceania 2025 (6th International Conference on Materials Science and Engineering). 2025. 招待講演
- 片岡 知歩, 宋 静文, 川上 亘作. トリアシルグリセロール液滴とコレステロールエステル液滴の巨大ベシクルへの導入:膜相分離の影響. 第86回応⽤物理学会秋季学術講演会. 2025.
- 山崎 智彦, パタク ソウミトラ, 谷田部 舞桜, 百武 篤也, 池袋 一典. パラレル型グアニン四重鎖構造をスキャホールドに用いた核酸アジュバント. 第19回バイオ関連化学シンポジウム. 2025.
- KAWAKAMI, Kohsaku. Elucidation of Nucleation Mechanism of Pharmaceutical Glass. 10th International Discussion Meeting on Relaxations in Complex Systems (10th IDMRCS). 2025. 招待講演
- 山崎 智彦, パタク ソウミトラ. CpG ODNのスキャホールドに用いたグアニン四重鎖構造のトポロジーが免疫活性化能に与える影響. 日本核酸医薬学会 第10回年会. 2025.
- Angela Quispe-Salcedo, Kiyoko Suzuki-Barrera, Mauricio Zapata-Sifuentes, YAMAZAKI, Tomohiko, Hayato Ohshima. Crosstalk between osteopontin and immune cells during pulpal healing following tooth injuries. 2025 15th Tooth Morphogenesis & Differentiation Conference. 2025.
- YAMAZAKI, Tomohiko. Using parallel-type G4 as a scaffold for delivery of immunostimulatory CpG oligodeoxynucleotides to immune cells. G4thering. 2025.
- Angela Quispe-Salcedo, Mauricio Zapata-Sifuentes, YAMAZAKI, Tomohiko, Hayato Ohshima. Effects of immobilized osteopontin on osseointegration after dental implantation into mice maxilla. 第24回日本再生医療学会総会. 2025.
- 谷田部 舞桜, パタク ソウミトラ, 山崎 智彦. パラレル型グアニン四重鎖構造にCpG 配列を導入した核酸アジュバント. つくば医工連携フォーラム2025. 2025.
2024
- Takeru Kanazu, Erika Komiya, Daimei Miura, Kaori Tsukakoshi, Kazunori Ikebukuro, YAMAZAKI, Tomohiko, Ryutaro Asano. Removal of DNA aptamer bound to the target protein using a DNA covalently binding protein. The International Chemical Congress of Pacific Basin Societies 2025 (Pacifichem 2025). 2024.
- KAWAKAMI, Kohsaku. Physical Chemistry for Practical Pharmaceutical Science. Biopham Master program. 2024. 招待講演
- KAWAKAMI, Kohsaku. Physical Chemistry for Practical Pharmaceutical Science. Biopham Master program. 2024. 招待講演
- 川上 亘作. ガラス/過冷却液体状態の有機低分子の結晶核形成に関する考察. ガラスに関連する分野の最先端研究. 2024.
- KAWAKAMI, Kohsaku. Establishing a Harmonized Physicochemical Profiling Platform for Therapeutic Oligonucleotides. AAPS 2024 PharmSci 360. 2024. 招待講演
- 川上 亘作. 溶解度/膜透過インタープレイ:in vitro膜透過試験とin vivo経口投与試験の比較. 第10回日本薬剤学会経口吸収フォーカスグループ合宿討論会. 2024.
- 川上 亘作. 核酸医薬品開発のための物性プロファイリング技術の開発. 第60回熱測定討論会. 2024. 招待講演
- 川上 亘作. イブプロフェンの結晶化における非晶質物性と結晶核形成挙動の関係. 第60回熱測定討論会. 2024.
- 川上 亘作. モダリティーシフトと製薬業界. 第50回BMSコンファレンス (2024). 2024. 招待講演
- 川上 亘作. 消化管内コロイドに可溶化された薬物の膜透過. 第75回 コロイドおよび界面化学討論会. 2024. 招待講演
- 片岡 知歩. トリアシルグリセロール液滴と巨大ベシクルの相互作用: 二重膜自発曲率の発生. 第85回応用物理学会秋季学術講演会. 2024.
- 正角優吏, 山崎 智彦, 川上 亘作, 百武 篤也. 酸素非依存的にDNAを光分解する光増感剤の応用に関する研究. 第18回バイオ関連化学シンポジウム. 2024.
- 片岡 知歩. 巨大ベシクルへのトリアシルグリセロール液滴の導入:リン脂質二重膜の自発曲率の発生. 第18回バイオ関連化学シンポジウム. 2024.
- YAMAZAKI, Tomohiko, PATHAK, Soumitra, 百武 篤也, 池袋一典. Immunostimulatory activity of CpG oligodeoxynucleotides forming parallel-type guanine quadruplex structure. 第18回バイオ関連化学シンポジウム. 2024.
- PATHAK, Soumitra, 浅野竜太郎, 池袋一典, 百武 篤也, YAMAZAKI, Tomohiko. Topology dependent cellular uptake of G-quadruplex scaffolded CpG oligodeoxynucleotides and their immunostimulatory effects. XXV International Round Table on Nucleosides, Nucleotides and Nucleic Acids at Katsushika Campus, Tokyo University of Science. 2024.
- YAMAZAKI, Tomohiko. Enhancement of immunostimulatory function of CpG oligodeoxynucleotides by using the guanine quadruplex structure as a scaffold. XXV International Round Table on Nucleosides, Nucleotides and Nucleic Acids at Katsushika Campus, Tokyo University of Science. 2024.
- KAWAKAMI, Kohsaku. Crack or Nuclei? What happens for pharmaceutical glasses annealed at low temperature?. 18th International Congress on Thermal Analysis and Calorimetry (ICTAC 2024). 2024.
- KAWAKAMI, Kohsaku. Lyophilization to Manufacture Mesoporous Phospholipid Particles. Michael J. Pikal Symposium. 2024. 招待講演
- 川上 亘作. ソフトマター科学による医薬品機能の最大化. TRiSTARコンソーシアム交流セミナー. 2024. 招待講演
- Angela Quispe-Salcedo, YAMAZAKI, Tomohiko, 大島 勇人. In vivo assessment of synthetic toll-like receptor 9 ligand molecules for the treatment of the afflicted dental pulp following tooth replantation in mice. The 22nd World Congress on Dental Traumatology. 2024.
- YAMAZAKI, Tomohiko, レ ボイ タオ グエン, PATHAK, Soumitra, 池袋一典, 浅野竜太郎. Evaluation of physical and immunostimulatory properties of CpG oligodeoxynucleotides forming guanine quadruplexes structure in complex with DOTAP. 第40回日本DDS学会学術集会. 2024.
- LI, Xia, HATTORI, Shinya, YAMAZAKI, Tomohiko, EBARA, Mitsuhiro, SHIRAHATA, Naoto, HANAGATA, Nobutaka. Rational design of iron-based coordination polymers for enhancing antitumor immunity. The 40th Annual Meeting of the Japan Society of Drug Delivery System. 2024.
- PATHAK, Soumitra, レ ボイ タオ グエン, 小田原 佑典, 百武 篤也, 浅野竜太郎, 池袋一典, YAMAZAKI, Tomohiko. A comparative study between three topologies of guanine-quadruplex forming CpG oligodeoxynucleotides to evaluate their potency as vaccine adjuvants. 第40回日本DDS学会学術集会. 2024.
- 山岸彩奈, YOSHIKAWA, Chiaki, YAMAZAKI, Tomohiko. Mechanical properties of nestin tail domain analyzed by tensile test using AFM. 21st IUPAB Congress 2024/IUPAB2024. 2024.
- 溝口 亮, 川上 亘作. 非晶質医薬品の核形成温度探索(1)これまでの評価事例と一般的な核形成温度探索手法. 日本薬剤学会第39年会. 2024.
- 岡田 ひとみ, 川上 亘作. 非晶質医薬品の核形成温度探索(4)比較的不安定な非晶質における核形成と結晶成長の影響理解. 日本薬剤学会第39年会. 2024.
- 川上 亘作. 多孔性レシチン粉体粒子を利用した経肺投与. 日本薬剤学会第39年会. 2024. 招待講演
- 徳本 大成, 川上 亘作. 非晶質医薬品の核形成温度探索(5)ケトコナゾール:比較的安定な非晶質の評価について考慮すべき点. 日本薬剤学会第39年会. 2024.
- 石塚 優也, 川上 亘作. 非晶質医薬品の核形成温度探索(6)テルフェナジン:核形成により生じる熱挙動及び物理安定性の影響について. 日本薬剤学会第39年会. 2024.
- 中込 純, 川上 亘作. 非晶質医薬品の核形成温度探索(2)ロラタジン:DSCによる至適温度の探索手法の確立. 日本薬剤学会第39年会. 2024.
- 石塚 太一, 川上 亘作. 非晶質医薬品の核形成温度探索(7)フルルビプロフェン:顕微鏡を用いた核形成温度の探索. 日本薬剤学会第39年会. 2024.
- 川上 亘作, 中込 純. 非晶質薬物の結晶化におけるクラック形成の影響. 日本薬剤学会第39年会. 2024.
- 鈴木 彰, 川上 亘作. 非晶質医薬品の核形成温度探索(3)ドロペリドール:非晶質状態の保存安定性を考察するためのDSCによる核形成温度の探索. 日本薬剤学会第39年会. 2024.
- Mai Hirokawa, KAWAKAMI, Kohsaku. Development of Physicochemical Profiling Platform for Therapeutic Oligonucleotides III Thermodynamic Analysis on Higher-Order Structure of Oligonucleotides. 2024 AAPS National Biotechnology Conference. 2024.
- Naoki Kawase, KAWAKAMI, Kohsaku. Interlaboratory Study of Multi-Attribute Method (MAM) for Antibody Therapeutics – Post-Translational Modification (1) C-terminal Lys Clipping. 2024 AAPS National Biotechnology Conference. 2024.
- Naoki Kawase, KAWAKAMI, Kohsaku. Interlaboratory Study of Multi-Attribute Method (MAM) for Antibody Therapeutics – Overview. 2024 AAPS National Biotechnology Conference. 2024.
- Ryota Tomioka, KAWAKAMI, Kohsaku. Interlaboratory Study of Multi-Attribute Method (MAM) for Antibody Therapeutics – Post-Translational Modification (1) Deamidation. 2024 AAPS National Biotechnology Conference. 2024.
- Mami Gomibuchi, KAWAKAMI, Kohsaku. Interlaboratory Study of Multi-Attribute Method (MAM) for Antibody Therapeutics – Post-Translational Modification (2) Oxidation. 2024 AAPS National Biotechnology Conference. 2024.
- Satomi Azumai, KAWAKAMI, Kohsaku. Development of Physicochemical Profiling Platform for Therapeutic Oligonucleotides IV Evaluation of Compactness of Oligonucleotides for Determining Their Higher-Order Structure. 2024 AAPS National Biotechnology Conference. 2024.
- Shoko Takeuchi, YAMAZAKI, Tomohiko, KAWAKAMI, Kohsaku. Development of Physicochemical Profiling Platform for Therapeutic Oligonucleotides. 2024 AAPS National Biotechnology Conference. 2024.
- YAMAZAKI, Tomohiko, KAWAKAMI, Kohsaku. Development of Physicochemical Profiling Platform for Therapeutic Oligonucleotides. V. Biological Function Analysis of Oligodeoxynucleotides. 2024 AAPS National Biotechnology Conference (NBC). 2024.
- 大山 薫, 佐藤 桂子, 川上 亘作. 難水溶性薬物の膜透過における胆汁酸ミセルの影響. 日本薬学会第144年会. 2024.
- 川上 亘作. 医薬品開発の国際競争力向上のための国内製薬企業水平連携. 日本薬学会第144年会. 2024. 招待講演
- 徳岡里奈, 吉川 千晶, 山崎 智彦. 原子間力顕微鏡を用いたネスチンテール領域の引張試験. 第71回 応用物理学会春季学術講演会. 2024.
- Quispe-Salcedo Angela, YAMAZAKI, Tomohiko. Effects of synthetic toll-like receptor 9 ligand molecules on the pulpal immunomodulatory responses and repair after injuries. 第129回日本解剖学会総会. 2024.
- KAWAKAMI, Kohsaku, SONG, Jingwen, HAN, Xue. Nucleation of celecoxib glass: Determination of nucleation temperature and impact of nuclei on dissolution/physical stability performances. 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology. 2024.
- LI, Xia, HATTORI, Shinya, YAMAZAKI, Tomohiko, EBARA, Mitsuhiro, SHIRAHATA, Naoto, HANAGATA, Nobutaka. Nanoengineering Design of Iron-based Coordination Polymers for Cancer Immunotherapy. つくば医工連携フォーラム2024. 2024. 招待講演
- PATHAK, Soumitra, YAMAZAKI, Tomohiko. Effects of different topologies of G-quadruplex structures used as scaffolds for CpG oligodeoxynucleotides on their stability, cellular uptake and immunostimulatory effects. つくば医工連携フォーラム2024. 2024.
- Feraliana, YAMAZAKI, Tomohiko. Aptamer-based sensor relies on plasmonic response. つくば医工連携フォーラム2024. 2024.
- レ ボイ タオ グエン, YAMAZAKI, Tomohiko. Gold nanoparticle-delivered guanine-quadruplex-based CpG oligodeoxynucleotides promote IFN-α secretion by size-dependent. つくば医工連携フォーラム2024. 2024.
2023
- 山崎 智彦, レ ボイ タオ グエン, ツ チ トラム アン. グアニン四重鎖構造形成によるCpG オリゴデオキシヌクレオチド担持DOTAPの機能向上. 第18回ナノ・バイオメディカル学会. 2023.
- 川上 亘作, 韓 雪, 宋 静文. 結晶核形成が非晶質セレコキシブの物性にお よぼす影響について. 第59回熱測定討論会. 2023.
- KAWAKAMI, Kohsaku. Regulation of Crystallization of Pharmaceutical Glasses Based on Understanding on Nuclei Formation. The 12th China-Japan Joint Symposium on Calorimetry and Thermal Analysis. 2023. 招待講演
- 片岡 知歩, 川上 亘作. ガラス支持脂質膜に埋め込んだトリアシルグリセロール液滴の オストワルド熟成. 第84回応用物理学会 秋季学術講演会. 2023.
- KAWAKAMI, Kohsaku. Solid-state Crystallization of Pharmaceutical Glass. The 4th ICePTi ( International Powder Technology Conference and Exhibition). 2023.
- KAWAKAMI, Kohsaku. Regulation of Nucleation Process of Pharmaceutical Glasses. The 9th International Discussion Meeting on Relaxations in Complex Systems (9IDMRCS). 2023. 招待講演
- KAWAKAMI, Kohsaku. Impact of liquid-liquid phase separation on oral absorption of supersaturated drugs. International Conference on Science and Technology of Pharmaceutical Glass. 2023. 招待講演
- MINAMI, Kosuke, 村田 朋大, YAMAZAKI, Tomohiko, YOSHIKAWA, Genki, ARIGA, Katsuhiko. Nanomechanical sensors for detecting trace amount water. 19th International Meeting on Chemical Sensors (IMCS 2023). 2023.
- KAWAKAMI, Kohsaku. REGULAION OF NUCLEATION AND CRYSTALLIZATION BEHAVIORS OF PHARMACEUTICAL GLASSES. 第26回IUPAC化学熱力学国際会議(ICCT-2023). 2023.
- 山崎 智彦, 川上 亘作. 合理的製剤設計を指向した核酸医薬品の物性評価プラットフォームの構築 (6)核酸アプタマーの機能評価. 日本核酸医薬学会 第8回年会. 2023.
- PATHAK, Soumitra, YAMAZAKI, Tomohiko. Effects of guanine-quadruplex topology on stability, cellular uptake, and immunostimulatory activities of CpG ODNs. 日本核酸医薬学会 第8回年会. 2023.
- 竹内 祥子, 山崎 智彦, 川上 亘作. 合理的製剤設計を指向した核酸医薬品の物性評価プラットフォームの構成(1)総論. 日本核酸医薬学会第8回年会. 2023.
- 廣川 芽衣, 川上 亘作. 合理的製剤設計を指向した核酸医薬品の物性評価プラットフォームの構成(5)キャピラリーゾーン電気泳動とDSCによる高次構造評価および粘度評価. 日本核酸医薬学会第8回年会. 2023.
- 小村 英恵, 川上 亘作. 合理的製剤設計を指向した核酸医薬品の物性評価プラットフォームの構成(3)円二色性スペクトル測定を用いた高次構造評価. 日本核酸医薬学会第8回年会. 2023.
- 山口 勝利, 川上 亘作. 合理的製剤設計を指向した核酸医薬品の物性評価プラットフォームの構成(2)NMRによる高次構造評価. 日本核酸医薬学会第8回年会. 2023.
- 東井 聡美, 川上 亘作. 合理的製剤設計を指向した核酸医薬品の物性評価プラットフォームの構成(4)キャピラリーゲル電気泳動法による高次構造評価. 日本核酸医薬学会第8回年会. 2023.
- レ ボイ タオ グエン, YAMAZAKI, Tomohiko. The ratio of guanine-quadruplex structure-based CpG oligodeoxynucleotides / cationic liposome regulates bifurcated cytokine profiles in immune cells. 日本核酸医薬学会 第8回年会. 2023.
- KAWAKAMI, Kohsaku, SONG, Jingwen, HAN, Xue. Control of nuclei formation of pharmaceutical glasses and its impact on supersaturated dissolution and storage stability. Gordon Research Conference Preclinical Form and Formulation for Drug Discovery. 2023.
- 川上 亘作, 宋 静文, 韓 雪. 非晶質医薬品の核形成温度探索および核形成が非晶質物性に与える影響について. 日本薬剤学会第38年会. 2023.
- 小林裕太, 川上 亘作. 抗体医薬品に対するMulti-attribute method (MAM) の国内発展を目指した製薬企業連携 -試験サイト間差低減に向けた検討 (3) C末端Lysクリッピング-. 第71回質量分析総合討論会. 2023.
- 五味渕真美, 川上 亘作. 抗体医薬品に対するMulti-attribute method (MAM) の国内発展を目指した製薬企業連携 –試験サイト間差低減に向けた検討 (2) 酸化修飾–. 第71回質量分析総合討論会2023大阪. 2023.
- 草間大志, 川上 亘作. 抗体医薬品に対するMulti-attribute method (MAM) の国内発展を目指した製薬企業連携. 第71回質量分析総合討論会. 2023. 招待講演
- 鋳物将明, 川上 亘作. 抗体医薬品に対するMulti-attribute method (MAM) の国内発展を目指した製薬企業連携 –試験サイト間差低減に向けた検討 (1) 脱アミド修飾–. 第71回質量分析総合討論会. 2023.
- Angela Quispe-Salcedo, YAMAZAKI, Tomohiko. Effects of synthetic CpG oligodeoxynucleotides on the healing process of heavily injured tooth pulp. 第22回日本再生医療学会総会. 2023.
- 徳岡里奈, 吉川 千晶, 山崎 智彦. 抗体修飾ナノニードルを用いたネスチン‐Clic1相互作用の力学解析. 第70回応用物理学会 春季学術講演会. 2023.
- レ ボイ タオ グエン, YAMAZAKI, Tomohiko. Regulation of bifurcated cytokine induction by CpG oligodeoxynucleotides/cationic liposome ratio in immune cells. つくば医工連携フォーラム2023. 2023.
- PATHAK, Soumitra, YAMAZAKI, Tomohiko. Parallel-type guanine-quadruplex structure improves the immunostimulatory effects of phosphodiester-based CpG oligodeoxynucleotides. つくば医工連携フォーラム2023. 2023.
その他の文献
2026
- 竹内 祥子, 川上 亘作. 核酸医薬品開発を加速するための物性評価基盤の構築. ファインケミカル. 55 [2] 12-18. 2026.
- 川瀬直樹, 小垣考弘, 富岡亮太, 川上 亘作. 抗体医薬品開発へのmulti-attribute method (MAM)の採用に対する国内製薬企業の対応状況. ファインケミカル. 55 [2] 6-11. 2026.
2024
- 山岸 彩菜, 吉川 千晶, 山崎 智彦, 中村 史. マイクロニードルアレイを用いた植物のゲノム編集 植物細胞内における効率的なCas9の放出. 化学と生物. 62 [12] 593-599. 2024. Open Access
- 片岡 知歩. リン脂質膜への炭化水素の侵入評価. Molecular Electronics and Bioelectronics. 35 [4] 207-211. 2024. Open Access
- KATAOKA, Chiho. Cover image. BIOPHYSICAL JOURNAL. 123 [13] 1857-1868. 2024.